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The significant disadvantage of using 3D printers primarily revolves around the initial setup costs. Setting up a 3D printing system typically requires a substantial investment in the printer itself, materials, and possibly software. This can be prohibitive for individuals or small businesses, as the total cost can be significantly higher compared to traditional manufacturing methods. Moreover, there's often a learning curve associated with operating 3D printers effectively, which can further add to the initial costs if training or specialized skills are needed.

While 3D printers can indeed produce large items, operate quickly and print in multiple colors, these features do not represent disadvantages. Instead, they highlight the capabilities and benefits of 3D printing technology. The initial expense stands out as a crucial barrier, particularly for those who are considering entry into the 3D printing market or integrating this technology into their operations.